Autosampler AS 6.1L

Fast and versatile analytical HPLC autosampler

Three different injection modes for high-precision and fast injection

The Autosampler AS 6.1L can inject from up to 768 positions when equipped with microtiter plates (either high or low formats) or from up to 108 standard 1.5 ml sample vials. The sample carryover is significantly minimized thanks to a highly-effective interior and exterior needle wash procedure. This autosampler is also fast and flexible: one complete sample injection cycle takes less than one minute, including needle wash. Three different injection modes are supported; “full loop filling” (highest precision and reproducibility), “partial loop filling” (variable volumes, e.g. for dilution series) and “µl pickup” (loss-free injection of extremely small sample volumes), allowing the user to optimize sample usage. The headspace pressure function prevents bubbles from forming in the vial during sample uptake. Precolumn derivatization is supported. For high-pressure injections, the autosampler is equipped with a so-called ILD™ valve (Intermediate Loop Decompression). This valve consists of a rotor-stator combination and includes a central port for depressurizing. For high-pressure applications, the sample loop is depressurized prior to receiving the sample. This way, the sample is not diluted with a solvent. Because the valve is switched extremely fast, pressure spikes are reduced. Analyses are more precise and wear of the column is reduced.


Autosampler Flow PathAnalytical
Maximum back pressure862 bar
Vial/plate dimensionswell plate dimensions according to ANSI SLAS 4-2004 (formerly ANSI/SBS 4-2004)
max. plate/vial height: 47 mm (incl. septa or capmat)
Injection volume range0.1 µl – 10 ml depending on sample loop
Sample loop100 µl
Dispenser syringe250 µl
Headspace pressurebuilt-in compressor, only for sample vials with septum
Switching time inj. valve< 100 ms
Piercing needle precision± 0.6 mm
Sample tray coolingnone
Vial detectionmissing vial/well plate detection by sensor
Wetted materialsETFE (buffer & needle tubing), stainless steel (sample needle, valve stator), Vespel (rotor seal), Kel-F (syringe valve), glass (syringe), PTFE (tip of syringe plunger)

General Information

Injection modesfull loop filling, partial loop filling and microliter pickup; PASA™ (pressure-assisted sample aspiration)
Injection accuracy0.2 µl for 250 µl injection syringe
Injection precisionfull loop filling: ≤0.3% RSD
partial loop injection at injection volumes>5 µl: <0.5% RSD
microliter pickup at injections>5 µl: <1.0% RSD
Sample carryover< 0.0015 % for partial loop (chlorhexidine)
< 0.0003 % with extended needle wash (s. Technical Note VTN0004)
Injections per vialmax. 9 injections
Injection cycle timeminimum 7 s from the same vial, 14 s from different vials;< 60 s for>100 µl sample injection in all injection modes, incl. 300 µl needle wash
Analysis timemax. 9 h, 59 min, 59 s
Inputs2 programmable TTL inputs (next injection, freeze, stop)
Outputs1 programmable relay output (inject marker, auxiliary, alarm)
ControlEthernet (LAN)
InterfacesLAN, analog
Ambient conditionstemperature range: 10–40 °C; 50–104 °F air humidity: 20 – 80%
Power supply95–240 V AC
Dimensions361 x 375 x 570 mm (W x H x D)
Weight30 kg
Autosampler AS 6.1L
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