PurityChrom® Basic

Basic License: 8 devices, 3 data channels, no autosampler supported

PurityChrom is a chromatography software specially designed for the area of preparative purifications and FPLC applications. 

PurityChrom provides a user-friendly and clearly structured interface. The system visualization offers a graphical representation of the purification system and allows easy handling even of complex flow processes. Furthermore, each device that is displayed in the fluidic scheme can be manually controlled, giving the opportunity to optimize, change and adapt your conditions during the run. Due to its high flexibility, methods can be developed according to specific demands.

You have the option to create a method based on volume, column volume, or time. There is also a possibility to pause or to change the method parameters during the run, which gives you complete control over your chromatography process. In PurityChrom you can define important functions in your method with variables. This allows you to write methods that can be adapted more flexibly to a specific sample or column, just before the run with only one click. In combination with the sequence table, a quick and easy method scouting provides you with the best method for your purification problem in less time. Furthermore, the sequence table helps to automate purification and CIP protocols.

For fractionation, you can use a fractionation valve as well as a fraction collector.

The function Solvent Supply calculates the consumption of solvent for the current run and prevents your column from running dry whereas the function Waste Management prevents the loss of your sample.

Current guidelines and regulations like 21 CFR part 11 are considered in the software. Accordingly, an user administration and an audit trail is implemented. PurityChrom allows flexible support of different devices from KNAUER and other manufactures. Please check for more information about supported devices the Release Notes of the latest PurityChrom version. With an unlimited number of free offline licenses, you can write methods and evaluate runs on any computer of your choice, without blocking the system. Furthermore, we offer free updates for PurityChrom MCC Plus as well as a demo license that can be used to get a first impression of the software user interface. 

The basic version offers all main features but is limited to 3 data channels and the control of eight devices, but does not support an autosampler. The upgrade version (A2652) supports 8 data channels and an unlimited number of devices including an autosampler. The 3D option (A2654) allows the support of a diode-array detector and the MS option (A2655) the usage of a mass spectrometer.


Software namePurityChrom® 5
Extensions / LicensesPDA / 3D UV, Mass spectrometry
Operating systemWindows XP, Windows Vista, Windows 7, Windows 8, Windows 10 (English or German only)


Stand-aloneLicense for controlling one system
Multi-user environmentOptional user administration with individual assignment of rights for individual users
Fields of applicationFPLC & Prep LC
Instrument connectionsupports RS-232, Ethernet, A/D-D/A interface
Recommended PC hardwareCPU/Memory: Pentium III or higher with at least 1 GHz; 32 or 64 bit; at least 512 MB RAM (Windows XP) and 2 GB (Windows Vista and higher)
Graphics: Screen with minimal resolution 1024 x 768
Connectors and Slots: USB for license dongle; COM, USB or LAN according to connected instruments
IntegrationReal-time analysis of peaks, automatic or manual integration and baseline correction
Security and GLPFDA 21 CFR Part 11 conformance
Automationvia sequences and autosampler control files
Presentation of resultsIndividual report configuration as pdf or csv
CalculationsColumn performance calculations according to DAB
Data import and exportComma Separated Value, AIA/ANDI, ChromStar Slice
Special featuresMethod creation based on volume or column volume; hold function; functionalized visualisation; direct control during a run; display of solvent supply; usage of variable values


FRC optionIncluded
FRC featuresControl of fraction collectors and KNAUER valve drives as fractionation valve, fractionation per Time/Level/Slope, rack info with filling level and chromatogram link
PDA optionspecial licence option; no 3D presentation
NoteFor autosampler control the upgrade licence is needed
PurityChrom® Basic
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