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amaZon speed ETD

 

The new amaZon speed ETD incorporates key inventions in ion trap mass spectrometry for unprecedented proteomics performance.

Explicitly designed to enhance capabilities in research areas, compound screening and identification, and detailed chemical analysis.

The amaZon speed ETD incorporates key inventions for unprecedented proteomics capabilities. The high dynamic range and complexity of proteomics samples due to post-translational modifications require maximum speed and sensitivity to capture as many peptides as possible. The amaZon speed ion ETD trap sets new standards in protein identification due to its enhanced MS/MS speed, new SWIFT isolation and SMART fragmentation.

Structural confirmation and screening applications in routine labs are well covered, as are protein ID and detailed target characterization.

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amaZon speed ETD

Key Features

  • Bottom-up proteomics identifying more low abundant proteins due to its greatly increased MS/MS duty cycle
  • Top-down sequencing (TDS) for the highest protein sequence coverage
  • Market leading mass accuracy for confidence in results
  • Leading dual ion funnel technology for unparalleled sensitivity
  • Outstanding ETD/PTR applications for full post-translational modification (PTM) analysis
  • SMART isolation and fragmentation
  • Unrivaled scan speed of 52,000 u/sec at a peak width < 0.5 u for resolution of doubly charged ions
  • High dynamic range
  • Speed & sensitivity to capture as many peptides as possible.
  • The amaZon speed ion ETD trap sets new standards in protein identification due to its
  • Enhanced MS/MS speed
  • New SWIFT isolation
  • SMART fragmentation.
  • Routine identification of more than 2500 unambiguously identified proteins in a single LC-MS/MS
  • The dual ion funnel transfer line is delivering absolute benchmark sensitivity

Sensitivity

Leading dual ion funnel technology offers unparalleled sensitivity.

Confidence

Market-leading mass accuracy ensures high confidence in identification.

Speed

Unrivaled MS/MS scan speed unravels the complexity of proteomics samples.

Complete PTM characterization by Electron Transfer Dissociation (ETD)

Posttranslational modifications (PTMs)

Many proteins execute their molecular function by reversible posttranslational modifications (PTMs), like phosphorylation for example.

The identification and unambiguous localization of the modification site is of major importance to understand the biological context. ETD preserves the modification of the peptide backbone and therefore allows clear assignment of the modification site.

The amaZon speed offers unrivaled performance through its proven sensitive, robust, and reliable ETD technology.

Glycopeptide analysis

Charge distribution and intensity of two different N-glycopeptides measured by Captive Spray and nanoBooster; A: CRPINATLAVEK and B: NVTSESTCCVAK

Peptide Sequence

Understanding relationships between structure, location, and function of glycoproteins requires detailed information about peptide sequence, glycan composition, and glycosylation sites. A wide variety of analytical approaches are employed to analyze intact glycoproteins, glycopeptides, and released glycans, with mass spectrometry playing a major role.

The performance of the amaZon speed ETD system for the analysis of N-glycosylated peptides in simple glycoprotein digest using Collision Induced Dissociation (CID) and Electron Transfer Dissociation (ETD) has been demonstrated.

The efficient combination of CID and oxonium-ion–triggered ETD during data acquisition – “Fragment Triggered ETD” – enables extensive protein sequence identification and detailed glycopeptide profiling in a single run, even in complex mixtures.

Combining the CaptiveSpray nanoBooster ionization source and Fragment Triggered ETD on the amaZon speed ETD platform greatly enhances glycopeptide analysis in protein mixtures.

System Components

ionBooster

ionBooster

The ionBooster enhances sensitivity and lowers detection limits by increasing ionization efficiency in a wide range of applications
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GC-APCI II

GC-APCI II

Greatest flexibility and highest performance with a combined GC frontend and high-resolution MS system for confident ID of unknown compounds using complementary MS technology
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Direct Insertion Probe (DIP)

Direct Insertion Probe (DIP)

Direct analysis of liquid and solid samples without tedious sample preparation. Add-on for the Bruker APCI II and APPI II ion sources.
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APPI II

APPI II

APPI is used for less polar or non-polar molecules that can not be ionized in either ESI or APCI.
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APCI II

APCI II

Used for less polar molecules where ESI fails to deliver reasonable quantities of ions
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VIP-HESI dual source

VIP-HESI dual source

Next generation in Mass Spectrometry sensitivity
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CaptiveSpray Ion Source

CaptiveSpray Ion Source

Stable and robust nanoflow LC/MS
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