amaZon speed

 

The amaZon speed ion trap series sets new analytical standards for proteomics and small molecule applications

The amaZon speed builds upon Bruker’s vast experience in ion trap technology and is designed specifically to enhance capabilities in research areas compound screening and identification, and detailed chemical analysis.

Modern ion trap systems offer reliably high performance in a rapidly changing world of mass spectrometry. Incredibly easy to use and with outstanding robustness, these systems deliver fastest MSn results with high sensitivity. The class leader in ion trap technology, Bruker Daltonics offers a comprehensive series of ion trap systems meeting the needs of any user.

Structural confirmation and screening applications in routine labs are well covered, as are protein ID and detailed target characterization.

amaZon speed

Key Features

  • Greatly increased MS/MS duty cycle for more productive data acquisition
  • High ion trap mass accuracy through proprietary RF generator design
  • Leading dual ion funnel technology for unparalleled sensitivity
  • Zero Delay Alternating for polarity switching with a minimum of 20 Hz MS acquisition speed
  • New SMART isolation and fragmentation
  • Unrivaled scan speed of 52,000 u/sec at a peak width < 0.5 u for resolution of doubly charged ions
  • Support of fastest UPLC applications at a maximum duty cycle
  • Delivering unmatched sensitivity by dual ion funnel inlet.
  • Provides several standard scan ranges up to 52,000 u/sec

Sensitivity

Leading dual ion funnel technology provides 10x higher MS/MS sensitivity.

Efficiency

Greatly increased MS/MS duty cycle for more productive data acquisition.

Speed

Fundamental improvements to the well proven amaZon platform offer dramatically enhanced speed.

Protein ID

Sets new standards in protein identification due to its enhanced MS/MS speed, new faster isolation and SMART fragmentation.

Turning Speed Into Solutions

The amaZon speed ion trap sets an analytical standard for small molecule and screening applications. Fundamental improvements to the well-proven amaZon platform offer dramatically enhanced

  • Speed
  • Mass resolution
  • MS/MS efficiency
  • Reproducible quantitation
  • Delivering unsurpassed performance

With a 10x higher MS/MS sensitivity over current platforms and Zero Delay Alternating switching at a minimum of 20 Hz MS acquisition rate, this ion trap system delivers increased performance to meet growing demand from the pharmaceutical, chemical, and clinical markets. 

Ion Trap performance for small molecule applications

MS for Structure Analysis

Identifying drug metabolites and verifying their structure play a vital role in pharma discovery and development. Software features like the FragmentExplorer are the ideal tools for structure confirmation, taking advantage of the fast and sensitive stepwise MS fragmentation of the amaZon speed ion trap. Bruker‘s MetaboliteTools software suite provides confident metabolite prediction as well as detection and interpretation of new compounds.

OpenAccess Workflows

The intuitive and workflow-oriented GUI of the Compass OpenAccess software supports the flexibility and speed of the amaZon speed as an ideal solution for multi-user industrial, clinical or teaching labs. The web-based client-server system is ideally suited for workflows such as:

  • quality control (QC)
  • recombinant protein MW

verification or automatic library searches.

Drug Quantitation

Reliable and routine quantification is a task so far reserved for triple quadrupole instruments. The enhanced speed and reproducibility of the amaZon speed in MRM experiments enables the reliable quantification of target compounds in diverse matrices.

Translating speed into proteomic information

Bottom-up analysis

The complexity of the proteome still challenges analytical technologies. The high dynamic range and complexity due to posttranslational modifications require maximum speed and sensitivity to capture as many peptides as possible.

The enhanced MS/MS speed, faster isolation, and SMART fragmentation capabilities of the amaZon speed ion trap set new standards in protein identification. This results in the identification of > 1200 unambiguously identified proteins in a single LC-MS/MS run from 1 µg E. coli digest.

Excellent dynamic range

The UPS-2 standard is a mixture of 48 proteins spanning a concentration range of 6 decades in total. The amaZon speed allows protein identifications over 5 concentration levels in a single run.

Survey view of an E.coli digest (1 µg) separated by a nano UHPLC using a 25 cm column and a 3 h LC gradient. MS detection was performed using the amaZon speed ETD system equipped with a CaptiveSpray ion source.

System Components

ionBooster

ionBooster

The ionBooster enhances sensitivity and lowers detection limits by increasing ionization efficiency in a wide range of applications
GC-APCI II

GC-APCI II

Greatest flexibility and highest performance with a combined GC frontend and high-resolution MS system for confident ID of unknown compounds using complementary MS technology
Direct Insertion Probe (DIP)

Direct Insertion Probe (DIP)

Direct analysis of liquid and solid samples without tedious sample preparation. Add-on for the Bruker APCI II and APPI II ion sources.
APCI II

APCI II

Used for less polar molecules where ESI fails to deliver reasonable quantities of ions
VIP-HESI dual source

VIP-HESI dual source

Next generation in Mass Spectrometry sensitivity
CaptiveSpray Ion Source

CaptiveSpray Ion Source

Stable and robust nanoflow LC/MS

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