The amaZon speed ion trap series sets new analytical standards for proteomics and small molecule applications
The amaZon speed builds upon Bruker’s vast experience in ion trap technology and is designed specifically to enhance capabilities in research areas compound screening and identification, and detailed chemical analysis.
Modern ion trap systems offer reliably high performance in a rapidly changing world of mass spectrometry. Incredibly easy to use and with outstanding robustness, these systems deliver fastest MSn results with high sensitivity. The class leader in ion trap technology, Bruker Daltonics offers a comprehensive series of ion trap systems meeting the needs of any user.
Structural confirmation and screening applications in routine labs are well covered, as are protein ID and detailed target characterization.
- Greatly increased MS/MS duty cycle for more productive data acquisition
- High ion trap mass accuracy through proprietary RF generator design
- Leading dual ion funnel technology for unparalleled sensitivity
- Zero Delay Alternating for polarity switching with a minimum of 20 Hz MS acquisition speed
- New SMART isolation and fragmentation
- Unrivaled scan speed of 52,000 u/sec at a peak width < 0.5 u for resolution of doubly charged ions
- Support of fastest UPLC applications at a maximum duty cycle
- Delivering unmatched sensitivity by dual ion funnel inlet.
- Provides several standard scan ranges up to 52,000 u/sec
Leading dual ion funnel technology provides 10x higher MS/MS sensitivity.
Greatly increased MS/MS duty cycle for more productive data acquisition.
Fundamental improvements to the well proven amaZon platform offer dramatically enhanced speed.
Sets new standards in protein identification due to its enhanced MS/MS speed, new faster isolation and SMART fragmentation.
Turning Speed Into Solutions
The amaZon speed ion trap sets an analytical standard for small molecule and screening applications. Fundamental improvements to the well-proven amaZon platform offer dramatically enhanced
- Mass resolution
- MS/MS efficiency
- Reproducible quantitation
- Delivering unsurpassed performance
With a 10x higher MS/MS sensitivity over current platforms and Zero Delay Alternating switching at a minimum of 20 Hz MS acquisition rate, this ion trap system delivers increased performance to meet growing demand from the pharmaceutical, chemical, and clinical markets.
Ion Trap performance for small molecule applications
MS for Structure Analysis
Identifying drug metabolites and verifying their structure play a vital role in pharma discovery and development. Software features like the FragmentExplorer are the ideal tools for structure confirmation, taking advantage of the fast and sensitive stepwise MS fragmentation of the amaZon speed ion trap. Bruker‘s MetaboliteTools software suite provides confident metabolite prediction as well as detection and interpretation of new compounds.
The intuitive and workflow-oriented GUI of the Compass OpenAccess software supports the flexibility and speed of the amaZon speed as an ideal solution for multi-user industrial, clinical or teaching labs. The web-based client-server system is ideally suited for workflows such as:
- quality control (QC)
- recombinant protein MW
verification or automatic library searches.
Reliable and routine quantification is a task so far reserved for triple quadrupole instruments. The enhanced speed and reproducibility of the amaZon speed in MRM experiments enables the reliable quantification of target compounds in diverse matrices.
Translating speed into proteomic information
The complexity of the proteome still challenges analytical technologies. The high dynamic range and complexity due to posttranslational modifications require maximum speed and sensitivity to capture as many peptides as possible.
The enhanced MS/MS speed, faster isolation, and SMART fragmentation capabilities of the amaZon speed ion trap set new standards in protein identification. This results in the identification of > 1200 unambiguously identified proteins in a single LC-MS/MS run from 1 µg E. coli digest.
Excellent dynamic range
The UPS-2 standard is a mixture of 48 proteins spanning a concentration range of 6 decades in total. The amaZon speed allows protein identifications over 5 concentration levels in a single run.