Pharmaceutical Polarimeter |


The AUTOPOL V PLUS Automatic Polarimeter is Rudolph’s top of the line six wavelength instrument. Its specifically designed with the input of the world’s largest pharmaceutical companies. This unit comes standard with 21CFR11 software. It also comes with Rudolph’s Patented TempTrol™ System. Therefore, it electronically heats and cools the sample to a specified temperature without the use of water circulation. This unit includes all wavelengths necessary to measure 99% of all monographs found in the USP, EP, JP and BP. In addition, IQOQ (Installation Quality Operation Quality) documentation is included with the instrument.

  • 6m HCl acid resistance: Silco Steel coating on the chamber temperature transfer surface and a Hastelloy measurement cell with NIST certificate certifying optical path length.
  • Comes with a NIST traceable quartz plate with three rotations: +0.998° Arc, +10.998° Arc, -10.000° Arc. Each rotation has a NIST certificate.
  • Intuitive Windows® based navigation architecture.
  • 3 USB ports.
  • Connect to Windows® based printer via USB.
  • Ethernet port for network cable connection.
  • Internet access allowing connection to Rudolph’s service department for remote testing and diagnostics.
  • Save measurement data to your network/server.
  • TempTrol™ Electronic Heating and Cooling.
  • Six Standard Wavelengths.


Autopol V Plus

Key Features

  • TempTrol™ — Electronic cooling & heating from 15°-35°C
  • Six Standard Wavelengths: 365nm, 405nm, 436nm, 546nm, 589nm and 633nm
  • 21CFR Part 11 Compliance: Electronic Signature and secure local electronic data storage
  • Domestic 3-year warranty and 20-year support guarantee
  • International warranty varies by country


Measuring ModeOptical Rotation Specific Rotation Specific Rotation Plus Concentration User Defined Scale Sugar Degrees °Z(ISS)
Measuring ScaleDegrees Arc, % Concentration
Measuring Range± 89° Arc Optical Rotation ± 999.99° Arc Specific Rotation 0-99.9% Concentration
Resolution0.001° Arc Optical Rotation 0.001% Concentration 0.001° Specific Rotation
Reproducibility0.002° Arc
Standard Model Accuracy0.002° up to 1°, 0.2% up to 5°, 0.01° above 5°
AP Model Accuracy and Resolution (Autopol V Plus Single)Accuracy: ±0.002° Arc over ±89.9° Arc Selectable Resolution 0.01°, 0.001°, 0.0001° Arc Optical Rotation
AP Model Accuracy and Resolution (Autopol V Plus Six Wavelength)Accuracy (546nm and 589nm): ±0.002° Arc over ±89.9° Arc Selectable Resolution 0.01°, 0.001°, 0.0001° Arc Optical Rotation
PrismGlan Thomson calcite quartz
Optical Wavelengths365nm, 405nm, 436nm, 546nm, 589nm, 633nm (other wavelengths available)
Wavelength SelectionTouch Screen Selectable: 6 Standard
TempTrol™ RangeAutomatic Electronic Heating & Cooling 15°-35°C
TempTrol™ Accuracy± 0.2°C
Temp. Probe Range10°-100°C
Temp. Probe Accuracy± 0.1°C
Acid ResistanceHastelloy™ measurement cell and Silco Steel™ sample chamber (standard)
Measurement Time4°/sec slewing rate & 5 sec nominal settling time
Light SourceTungsten-halogen 6V, 20W, avg. 2,000 hr life
Sample ChamberAccepts sample tubes up to 200mm
Data Storage32 GB Non-removable Compact Flash
Communication Interface3 USB Ports, 2 RS232 Ports, Ethernet Port for Network Connection
CalibrationAutomatic calibration via touch screeen
Operating SystemWindows® Embedded
Display10.4 inch diagonal, 800×600 pixels, color, Flat Panel Monitor with Resistance Touch Screen Interface, 200 nits brightness, gasketted for spill protection
User InterfaceTouchscreen
Automatic Sensitivity ControlMeasures samples with transmittance as low as 0.01% (up to O.D. 4.0)
Input Power85-260 VAC; 48-62 Hz, 150-200 Watts consumption
Operating Dimensions32″W x 11.5″H x 19.5″D 813mm W x 292mm H x 457mm D
Shipping Dimensions43″W x 28″H x 23″D 1411mm W x 919mm H x 722mm D
Operating Weight90 lbs (41 kg)
Shipping Weight140 lbs (64 kg)


The most stringent
pharmaceutical requirements

Unmatched Accuracy: ± 0.0003° Arc

For Racemic Solutions and very low concentration samples, the Autopol® VI provides unmatched 4th decimal optical rotation accuracy of ±0.0003°Arc over ±1°Arc. Instrument performance for readings between -1 and 1° Arc is: Resolution ±0.0001, Reproducibility ±0.0002, and Accuracy ±0.0003.

The Industry Standard Polarimeter

The Autopol® V PLUS and Autopol® VI have the validation tools and features to satisfy today’s global pharmaceutical companies, including: instrument level 21CFR Part 11 compliance, NIST traceable calibration standards and a global list of installations. Rudolph Research has thousands of satisfied customers who praise the Autopol® V PLUS and Autopol® VI quality, accuracy and reproducibility.

The AUTOPOL® IV and V by Rudolph
Simply the Best

Full Compliance
21CFR Part 11

The Autopol® V 21CFR Part 11 software module is easily enabled through the user-friendly touch screen. This module gives you full compliance with:

  • Electronic signature
  • Access levels
  • Internal write-protected storage
  • Unique passwords
  • Write protected documents sent directly to server
  • Audit trail


The AUTOPOL® V Automatic Digital Polarimeter comes standard with six wavelengths: 365nm, 405nm, 436nm, 546nm, 589nm, 633nm. Wavelength selection is completely automatic and is accomplished by the push of a button. There are no lamps or filters to manually remove or insert.

The tungsten-halogen lamp employed in the AUTOPOL® V Polarimeter is a compact, reliable, low-cost, high-intensity light source that allows any desired wavelength in the visible spectrum to be selected by means of a narrow band multilayer interference filter. The AUTOPOL® standard 10nm bandwidth is specified to permit high energy throughput and sensitivity for sample transmittances of only 0.01 % (O. D. = 4), while minimizing the effects of sample ORD and color.

Display and Correction

The AUTOPOL® IV Automatic Essential Oils Polarimeter comes standard with a temperature probe which can be inserted into the Polarimeter cell as shown to the left. The temperature of either the sample compartment or the solution itself can be continuously displayed.

Print Format

Numerous parameters, such as sample name, tube length, concentration, wavelength, time and date, temperature correction and statistics can be printed after each polarimeter measurement or after a group of measurements. This is accomplished by designating the required parameters, via menu entry, during the print format setup mode. A sample printout is shown below.

Print your customized Certificate of Analysis including your company logo directly from the Autopol IV touch screen

Capable of making multiple measurements on a single sample and reporting complete statistical data and all measurement results

The Rudolph

Many users prefer to load cells with samples outside of the Polarimeter. When this fits with your workflow, Rudolph has engineered a tool to assist you, the Rudolph Polarimeter FillStationTM. Designed to sit on your laboratory bench or under your fume hood and assist you in loading your Rudolph Polarimeter cell easily and reliably, the FillStationTM holds the cell at the right angle, so you always fill the cell from bottom to top. Using a syringe, you inject the sample until it begins to appear at the top port. Once filled, the monitoring light will become bright, and you know you have a full cell free of air bubbles that is ready for measurement. Cap, the Top Cell Port, remove the syringe, cap the Lower Port and go!

  • The cell is held at the right angle and filled from the bottom just the way Rudolph cells were designed to be filled. Perfect every time.
  • Filling from the bottom to top moves any air with the potential to cause a bubble up and out of the cell.
  • Once you see the monitoring light go to bright there is no question that the cell is properly filled.
  • Verification of air free sample loading for even inexperienced operators.
  • Helps eliminate contact with acids, bases, or any sample the user does not want to come in contact with.
  • Less experienced operators can learn to reliably fill cells with minimal training.

System Components

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