Over time, instruments will wear, causing them not to run as smoothly or report results as accurately. Within this, part of the instruments can be replaced with new or refurbished spare parts, preventing downtime and keeping them working effectively.
Target Analysis’ repair services for GCs, HPLCs, mass spectrometers, and other lab instruments include warranty coverage, service agreements, and preventative maintenance. Whether you are seeking instrument repair or scheduling a service call for lab equipment repair.
Our experienced technicians will quickly restore your pump to top performance – regardless of its age. We offer comprehensive on-site support for vacuum components and systems, troubleshooting, maintenance, and repairs.
Target Analysis IQ/OQ/PQ procedures strictly follow good laboratory practices (GLP), which require that all laboratory instrumentation be inspected, cleaned, and maintained. We provide an independent and comprehensive testing service for Mass Spectrometry & Chromatography instruments to help you meet your regulatory and operational requirements and standards.
The philosophy behind our services is that we can support all the scientific instruments that we sell. Our technical department is trained and certified to offer a complete system service across multiple brands and models, including Mass Spectrometers (MS), Liquid Chromatographs (LC), Gas Chromatographs (GC), Autosamplers, Detectors & Peripherals
Remote support provides additional service through remote software to resolve instrument issues before a technician is dispatched. Our remote support team works with you via phone and software to remotely control your system to troubleshoot, repair or assist. This additional level of support allows for faster resolution of issues and ultimately reduces instrument downtime.
Application support is a service provided by our team that gives you a strategy and technique to quickly and confidently develop high-quality methods. You will learn a proven technique that will guide you step-by-step through the process of method development, applying principles that will make the process more efficient. Application support can take the form of a course, training, or development of an analytical method based on your real samples.
Omics technologies adopt a holistic view of the molecules that make up a cell, tissue, or organism. Target Analysis can provide unique solutions for bioinformatics services for proteomics and metabolomics workflows. Based on our experienced team members, we can readily meet the rigorous demands of various fields, such as life sciences, nutrition research, etc.
Target Analysis was founded in 2013 by a team of experienced scientists and engineers.
Through the trust of our customers and partners, Target Analysis has managed to create a team with experienced and trained staff, which undertakes the installation of instruments, staff training, and after-sales support with spare parts, consumables, and certified reference materials. The company’s know-how is constantly expanding and is ready to take on any challenge to solve your analysis issues.
A revolution in clinical and pharmaceutical sample processing
Instead of punching blood spots the DBS Autosampler uses clamps and dried blood spots or dried matrix spots which are directly desorbed as a liquid sample for analysis. This enables a completely automated workflow for DBS analysis. Dried blood spot (DBS) sampling is an emerging technology for bioanalysis, offering easy, convenient cost-effective sample collection, transport, and storage. Axel Semrau‘s revolutionary DBS autosampler™ has set a new standard for bioanalysis. It maintains the integrity of the sample through automation using our unique direct elution FTD™ technology for sample preparation. Can you only imagine its potential?
CHRONECT DBS maintains the integrity of the sample by automation and provides valuable benefits:
Unique and patented FTD™ technology for sample preparation
Various clamps available for spot sizes of 2, 4, 6, or 8 mm
Intelligent camera with image analysis software provides accurate spot detection and positioning as well as identification via 1D or 2D barcode
Storage, monitoring, and tracking of samples
Automatic internal standard addition via loop injection with HPD (high-pressure dispenser) and integrated mini pump during blood spot desorption, best precision and accuracy
Map Information Store
HotCap: heated capillaries for better desorption, minimizes hematocrit effect in full spot analysis of therapeutic drugs
Standard capacity: 96 DBS cards with 4 spots per card allow 384 sample measurements
Excellent sensitivity for a wide range of analytes
Very good precision, linearity and accuracy over a wide range of analytes
Control via CHRONOS, optimal integration into LC or GC-MS/MS systems or offline use for free further use of the eluates
Flow-through desorption concept (FTD™)
Leak-tight clamp heads provide direct elution of DBS from cards without punching discs.
Partial spot, full spot
Replaceable: sizes 2 mm, 4 mm, 6 mm and 8 mm available. SS316. Leak-tight up to 200 bar for 2 mm, 4 mm and 6 mm clamp heads. Leak-tight up to 100 bar for 8 mm clamp head.
4 spot Whatman or PerkinElmer type DBS card in a cassette format,
Intelligent Vision Camera (IVC™)
Camera designed to provide: missing card detection, accurate positioning of DBS cards in the clamp, 1D and 2D sample barcode identification, full or partial spot desorption options, full image capture for sample information storage, tracking and traceability.
Internal standard loop
Internal standard pump max. 95 μL/s
To dry fluid lines and clamp heads after desorption and wash.
Clamp positioning precision
SS stator and PEEK rotor seal, bore 0.25 mm, 1/16““ connection ports, except port 4 (1/32
Valve switching time
RSD < 1%; due to paper quality larger values are typically obtained
Reproducibility internal standard
RSD < 1%
Cycle time, typically using HPD™
150 s including desorption and wash
from card retrieval to ready to desorb 20 s
Wetted parts in sample flow path
SS316, PTFE, PEEK
In dispenser and wash lines : Tefzel, Teflon, PEEK, KelF, glass.
Dimensions DBS-A with CHRONECT Symbiosis
535 mm x 540 mm x 698 mm (WxDxH)
Weight DBS-A with CHRONECT Symbiosis
32 kg Symbiosis
CE, RoHS, FCC, ICES-01
Safety standards applied
IEC61010-1, IEC61010-2-081 and IEC61010-2-010
EMC standards applied
IEC61326-1, CISPR11, 47 CFR part 15
UL and CSA approved
ISO 9001 and ISO 13485 certified
LED white LED with on/off control
Door open status
100 – 240 V AC +/- 10%, 50/60 Hz
2 x 2.5 AT, 250V, 1500A breaking capacity, IEC 60127-2, UL recognized
A Revolution in DBS sampling
FTD™ – Flow-Through Desorption No manual intervention required with our innovative patented technology. Direct elution of DBS from cards enables optional online clean-up and analyte separation by SPE prior to analysis in an automated workflow. Replaceable clamp head sizes of 2, 4, 6 or 8 mm clamp and seal filter paper cards up to pressures of about 200 bar (up to 100 bar for the 8 mm clamp). Desorption solvent is delivered by a high-pressure dispenser (HPD™).
IVC™ – Intelligent Vision Camera Accurate spot positioning and sample traceability is vital for accuracy. Our camera, one the one hand, has been designed for accurate positioning of DBS cards in the high pressure clamp for direct Flow-through desorption of bloodspots. On the other hand it also offers sample barcode identification for 1D or 2D barcodes, full or partial spot desorption options and full image capture for sample information storage.
AISA™ – Automated internal Standard Addition Accurate automated internal standard addition using a loop injection method. A specified volume of internal standard is loaded into a loop using an integrated mini pump. Then, the internal standard is then added to the sample during desorption of a blood spot using a high-pressure dispenser (HPD™).
HotCap™ – individual Heating of Solvents HotCap™ is an optional capillary that rapidly heats solvents to improve desorption and sample recovery. It has been shown that temperature-enhanced conditions significantly increase analyte recovery and reduce the dependency of recovery on the blood Ht level. The effective HotCap™ technique significantly increases recoveries of cyclosporine A (Ht 0.65), Everolimus,Sirolimus and Tacrolimus.
CHRONOS Control of DBS is integrated in the reliable software platform CHRONOS from Axel Semrau. CHRONOS controls all CHRONECT Symbiosis online SPE solutions and all PAL sampler. CHRONOS is open to most chromatography data systems. This enables the user to handle the entire system DBS and SPE/LC/MS under one platform. Automation of full workflows can be managed by CHRONOS.
Traditional DBS Workflow
Extended sample capacity and automation options Expandable capacity – from a single card to a 96 card feeder. Four sample spots per card allow for automatization of the measurement with up to 384 samples. Complete Workflows can be automated. Different set-ups are possible: Direct online couplings like DBS-LCMS or direct injection DBS-MS with CHRONECT DBS and High Pressure Dispenser HPD™, automated desorption and collection in vials to use different analytical methods (LCMS, GCMS or other) after extraction from the card with CHRONECT DBS Collect or online couplings including Solid Phase Extraction (SPE) with CHRONECT DBS Xtraction.
Improved stability of analytes and less virality Improved stability of the target analytes by using DBS is another advantage of this technique. Enzyme activities are restrained by the dryness, so even unstable hormones can be stored and analyzed over a longer period of time. DBS improves stability for most analytes. Dryness also reduces virality of samples which improves the safe handling of samples.
Easy transport and storage Dried blood spot (DBS) sampling offers easy, convenient, cost-effective sample transport and storage. The cards are small and lightweight. The handling of cards is comfortable. Transport is easy and inexpensive. Transport and storage are much more efficient compared to transport and storage of vials with blood.
Applications Many applications are described in different formats – application notes, scientific posters or publications.
Glutathione (biomarker for autism)
Anabolic steroid esters in cattle
Fentanyl and analoges
TDM of nortriptyline
Opioids for pain management
Nicotine and metabolites
Guanfacine, drug for ADHD treatment
Acylcarnitines, amino acid and lipids
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