maXis II

 

Heralds a new era in accurate-mass LC-MS/MS
 

maXis II is the market-leading high-resolution LC-QTOF, leading the way in QTOF technology with unprecedented performance across wide-ranging applications, to resolve the most demanding analytical challenges.

A full range of specified performance parameters is delivered simultaneously.

Bruker’s Ultra-High Resolution QTOF (UHR) technology has reached new standards in accurate-mass LC-MS/MS. In addition, the system offers Electron-Transfer Dissociation (ETD) capabilities for sequence analysis of intact proteins including monoclonal antibody subunits.

Furthermore, native state samples, including antibody-drug conjugates, can be measured at these enhanced performance levels (Native Mass Spectrometry).

maXis II

ULTRA-HIGH RESOLUTION LC-QTOF MS

Unmatched performance to resolve demanding analytical challenges

Performance

Record-breaking full sensitivity resolution (FSR) of > 80,000.

High-definition

Five orders of magnitude dynamic range achieved at UHPLC speeds due to 50 GBit/sec sampling technology-definitive trace analysis from complex, high-background matrices.

Plug and play

One-shot acquisition with triple-quadrupole sensitivity ensuring qualitative and quantitative results in one LC run with fastest time-to-success.

Easy expertise

Intelligent self-optimizing MS/MS routines for expert-caliber results first time and dedicated application packages.

From Small Molecules up to Megadalton Complexes

Antibody Characterization – Intact and Subunit Analysis

Enhanced resolution and mass precision – for highly precise and accurate determinations of the monoisotopic masses of both the Light and Heavy Chains of mAb’s on an LC timescale for automated confirmation of product identity and detection of impurities. Superb raw data quality allows for fast and easy detection of modifications (including deamidation) in biotherapeutic characterization without the need for time and cost intensive digestion and peptide mapping of the entire antibody.

Native Mass Spectrometry (optional)

The High Mass Option combines adjustable Funnel 1 pressure with in-source CID on the maXis II to permit efficient desolvation and ionization of the native sprayed analyte without sacrificing other performance vectors. Thereby enabling easier application of native MS or high mass workflows for the structural investigation of larger proteins and/or protein complexes (including antibody drug conjugates)

Complex Protein Mixture

The maXis II delivers superb dynamic range (5 orders of magnitude) at UPLC speeds enabling analysis of protein mixtures in complex, high-background matrices. For example > 1000 proteoforms resolved in a 35 min run from an undiluted serum sample.

  • Sub-ppm mass accuracy & isotopic accuracy
  • Isotopic resolution even for proteins > 40Kda
  • MS/MS available for proteoform ID

Robust LC-ETD capabilities

(with novel nCI source and Gas Enrichment Apparatus (optional)). Top-down MW measurement plus LC-ETD sequence data for rapid detection and localizion of post-translational modifications (PTMs) in mAb’s

System Components

ionBooster

ionBooster

The ionBooster enhances sensitivity and lowers detection limits by increasing ionization efficiency in a wide range of applications
GC-APCI II

GC-APCI II

Greatest flexibility and highest performance with a combined GC frontend and high-resolution MS system for confident ID of unknown compounds using complementary MS technology
Direct Insertion Probe (DIP)

Direct Insertion Probe (DIP)

Direct analysis of liquid and solid samples without tedious sample preparation. Add-on for the Bruker APCI II and APPI II ion sources.
APPI II

APPI II

APPI is used for less polar or non-polar molecules that can not be ionized in either ESI or APCI.
APCI II

APCI II

Used for less polar molecules where ESI fails to deliver reasonable quantities of ions
VIP-HESI dual source

VIP-HESI dual source

Next generation in Mass Spectrometry sensitivity
CaptiveSpray Ion Source

CaptiveSpray Ion Source

Stable and robust nanoflow LC/MS

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