NanoLab 3D™

Dynamic light scattering even at high concentration

Error-free particle sizing even at high concentration 

Conventional DLS instruments carry the risk that multiply scattered light can lead to incorrect particle size measurements without ever warning you. Especially with concentrated samples, complex sample preparation and dilution are necessary. This is exactly where our NanoLab 3D comes in.

The NanoLab 3D™ is a compact DLS instrument for particle sizing that is based on the groundbreaking and patented Modulated 3D Cross-Correlation technology. It efficiently suppresses multiple light scattering and therefore sample dilution is no longer required for most samples.

NanoLab 3D™

Key Features

  • Advanced DLS particle sizing: Cumulant and CORENN analysis
  • DLS microviscometry
  • Applicable to diluted as well as highly concentrated samples
  • Small sample volume – down to 4 µL (optional)
  • Particle sizing from 0.15 nm to 5 µm radius
  • Temperature range: 4°C to 85°C *
  • Monitors time-dependent processes
  • Compact and robust design
  • Online support for all customers
  • Conforms to ISO 22412

Specifications

Technology     Modulated 3D cross-correlation DLS (EU Patent)
Hydrodynamic radius 0.15 nm-5μm*
Cuvette sizes​ 3 x 3 mm, 5 x 5 mm, 10 x 10 mm (optional 1 x 1 mm)
Maximum concentration​ 40 % w/v*
Sample volume​ 50 μL —2 mL (optional 4 μL)
Temperature range 4° C to 85° C (+/-0.02 °C)** measured online
Laser class 1
Wavelength 638 nm
Laser power     120 mW
Scattering angle 90°
Detection Single mode fiber with high performance APD. QE 65 %
Correlator Two channel multiple tau, 12.5 ns -1 h, 320 channels
Laser attenuator System with online incident power measurement
Software Including Cumulant, CONTIN, CORENN analysis
Laboratory requirements < 60 % relative humidity and T = 17 to 26 °C
Size 45 x 45 x 30 cm
Weight Approx. 30 kg

Small Volume

Innovative technology in Swiss quality

Fast

Expert team,
error-free results

Easy-to-use

Easy usage and clear
data processing

Support

Customer care
and maintenance

Dynamic Light Scattering (DLS)

Dynamic light scattering is the technology of choice to measure the size of nanoparticles dispersion. Driven by Brownian motion, the particles move within the medium, causing the intensity of scattered light to fluctuate. The statistics of these fluctuations are reflected in the correlation function. Since the size of the particles influences the particle movement and thus the statistics, DLS can extract the particle size distribution from the obtained correlation function.

Can you trust your measurements?

Unlike standard DLS instruments, the NanoLab 3D uses two laser beams which are modulated at very high frequency. The instrument thus performs two light scattering experiments simultaneously. By cross-correlating the signals of the two experiments, we improve precision by eliminating multiple scattering that otherwise causes an undetectable error in all samples that are not substantially diluted! Only the Modulated 3D technology fully removes multiple scattering arising in concentrated samples, allowing measurements up to the highest concentrations guaranteeing the trustworthiness of the measurement.

Powerful analytical tools

We designed the software of the NanoLab 3D for both DLS experts as well as beginners without specific training. Anything from one simple, yet reliable measurement, to a complex series of multiple measurements can be performed within just a few clicks. Powerful analytical tools allow highly customizable data display and export while saving all results in a well-organized and comprehensive database. Analytical tools included are Cumulant and the LSI proprietary algorithm CORENN.

AI-powered algorithm

CORENN is a novel advanced machine learning algorithm to extract the particle size distribution (PSD) from a DLS measurement. CORENN is the only DLS inversion algorithm that leverages on advanced signal approximation techniques and a unique theoretical estimate of the signal noise to yield extremely reliable results, robust against experimental distortions, thus enabling the end-user to obtain the true PSD from real world DLS experiments. The figure on the left shows a DLS measurement of a particle mixture of 4 nm and 45 nm. Only CORENN is able to correctly determine the two populations.

System Components

Cuvettes

Cuvettes

four different standard sizes of glass cuvettes

  • 1 x 1 mm
  • 3 x 3 mm
  • 5 x 5 mm
  • 10 x 10 mm

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