Over time, instruments will wear, causing them not to run as smoothly or report results as accurately. Within this, part of the instruments can be replaced with new or refurbished spare parts, preventing downtime and keeping them working effectively.
Target Analysis’ repair services for GCs, HPLCs, mass spectrometers, and other lab instruments include warranty coverage, service agreements, and preventative maintenance. Whether you are seeking instrument repair or scheduling a service call for lab equipment repair.
Our experienced technicians will quickly restore your pump to top performance – regardless of its age. We offer comprehensive on-site support for vacuum components and systems, troubleshooting, maintenance, and repairs.
Target Analysis IQ/OQ/PQ procedures strictly follow good laboratory practices (GLP), which require that all laboratory instrumentation be inspected, cleaned, and maintained. We provide an independent and comprehensive testing service for Mass Spectrometry & Chromatography instruments to help you meet your regulatory and operational requirements and standards.
The philosophy behind our services is that we can support all the scientific instruments that we sell. Our technical department is trained and certified to offer a complete system service across multiple brands and models, including Mass Spectrometers (MS), Liquid Chromatographs (LC), Gas Chromatographs (GC), Autosamplers, Detectors & Peripherals
Remote support provides additional service through remote software to resolve instrument issues before a technician is dispatched. Our remote support team works with you via phone and software to remotely control your system to troubleshoot, repair or assist. This additional level of support allows for faster resolution of issues and ultimately reduces instrument downtime.
Application support is a service provided by our team that gives you a strategy and technique to quickly and confidently develop high-quality methods. You will learn a proven technique that will guide you step-by-step through the process of method development, applying principles that will make the process more efficient. Application support can take the form of a course, training, or development of an analytical method based on your real samples.
Omics technologies adopt a holistic view of the molecules that make up a cell, tissue, or organism. Target Analysis can provide unique solutions for bioinformatics services for proteomics and metabolomics workflows. Based on our experienced team members, we can readily meet the rigorous demands of various fields, such as life sciences, nutrition research, etc.
Customized training solutions from sample preparation to data analysis. Specially designed courses to meet today’s ever-increasing demands for analytical performance, productivity and ease of use!
Target Analysis was founded in 2013 by a team of experienced scientists and engineers.
Through the trust of our customers and partners, Target Analysis has managed to create a team with experienced and trained staff, which undertakes the installation of instruments, staff training, and after-sales support with spare parts, consumables, and certified reference materials. The company’s know-how is constantly expanding and is ready to take on any challenge to solve your analysis issues.
See how our customers are using Target Analysis’ products to transform their research and ultimately make discoveries that help change the way we see the future.
Expanding the Capabilities of High-Throughput 4D-Proteomics™
Powered by the 4th generation TIMS-XR and advanced digitizer technology for high dynamic range and analytical depth in quantitative cell and tissue proteomics.
The new timsTOF HT mass spectrometer offers a higher dynamic range for unmatched analytical depth and quantitation in high-throughput proteomics experiments. The timsTOF HT is fully CCS-enabled and supports all PASEF® acquisition modes including PASEF®, dia-PASEF® and prm-PASEF® achieving flexibility in 4D-Proteomics™. Simply uncompromised proteomic depth at scale.
Expanding the capabilities of high-throughput 4D-Proteomics™
Speed
PASEF® technology on the timsTOF HT achieves 150 Hz sequencing speed without affecting resolution or sensitivity.
Robustness
The unique instrument design enables robust performance and routine operation over thousands of samples without requiring cleaning.
Sensitivity
High charge capacity of the 4th generation TIMS-XR for increased analytical depth.
Selectivity
Adding ion mobility separation to the advanced quadrupole and Time-of-Flight capacities.
Important Features to Consider
TIMS based ion mobility separation and CCS-enabled analysis
The new timsTOF HT mass spectrometer is equipped with the 4th generation high capacity TIMS-XR analyzer and advanced digitizer technology (ADT). It offers higher dynamic range for unmatched analytical depth and quantitation in high-throughput proteomics experiments. The timsTOF HT is fully CCS-enabled and supports all PASEF® acquisition modes including PASEF®, dia-PASEF® and prm-PASEF® achieving flexibility in 4D-Proteomics™. Simply uncompromised proteomic depth at scale.
Benefits
PaSER
Maximize your identification depth and throughput with the new capabilities of PaSER, our “run and done” database search platform. TIMScore™ and TIMS DIA-NN take full advantage of the CCS for more accurate protein identification on the fly.
Applications
Enabling rapid tissue proteome analysis with dia-PASEF®
Rapid cardiac tissue proteomics. Different amounts of a murine heart proteome digest were analyzed in triplicates with short liquid chromatography gradients and dia-PASEF®. At the highest sample load, we identified in total 4700 protein groups spanning more than five orders of magnitude in relative abundance. Raw data were processed with DIA-NN in library-free mode and protein copy numbers were estimated with the ‘proteomic ruler’ approach.
Unprecedented depth in cell lines with dia-PASEF®, TIMS DIA-NN and PaSER
For even higher proteome depth, increased protein digest loads improve identifications. A tryptic digest of human cell line K562 (Promega) was analyzed using a nanoElute system at 250 nL/min with 60 min separation time on an Aurora column (25cm, 75 μm ID, IonOpticks). timsTOF HT operated in dia-PASEF® mode using 100 ms TIMS separations. Data was processed with TIMS DIA-NN using a predicted library from uniprot (human reviewed).
Targeted Plasma Proteomics: quantify more than 550 proteins with a 30 min gradient
We combined the use of a PQ500 (Biognosys) Stable Isotopic Standard (SIS) with a dia-PASEF® based appoach using a 30 min gradient on a timsTOF HT. 578 proteins (corresponding to 804 peptides) could be accurately quantified with a > 99% data completeness. This approach combines the selectivity and sensitivity of traditional SMS/MRM methods with an easy-to use acquisition setup, also allowing to define new targets a posteriori.
Nano LC columns for best results on higher sample loads
Using a PepSep Twenty-five series column (150 μm ID, 1.5 μm particle size), average peak of widths less than five seconds were achieved for K562 tryptic digest (Promega) sample loads up to 1600 ng. A gradient time of 41 min was adequate for efficient peptide separation, resulting in homogenous peptide elution across the gradient even at high peptide loads.
A) The TIMS-XR allows for increased ion capacity for sample loads beyond 200 ng. Reproducible identification of ~ 6900 protein groups and more than 86,000 unique peptides.
B) Number of identifications using the PaSER real-time search engine with TIMScore™ for dda-PASEF of up to 1600 ng K562 tryptic digest. Error bars indicate standard deviation for 5 replicates with mean displayed above histogram.
Greatest flexibility and highest performance with a combined GC frontend and high-resolution MS system for confident ID of unknown compounds using complementary MS technology
