Over time, instruments will wear, causing them not to run as smoothly or report results as accurately. Within this, part of the instruments can be replaced with new or refurbished spare parts, preventing downtime and keeping them working effectively.
Target Analysis’ repair services for GCs, HPLCs, mass spectrometers, and other lab instruments include warranty coverage, service agreements, and preventative maintenance. Whether you are seeking instrument repair or scheduling a service call for lab equipment repair.
Our experienced technicians will quickly restore your pump to top performance – regardless of its age. We offer comprehensive on-site support for vacuum components and systems, troubleshooting, maintenance, and repairs.
Target Analysis IQ/OQ/PQ procedures strictly follow good laboratory practices (GLP), which require that all laboratory instrumentation be inspected, cleaned, and maintained. We provide an independent and comprehensive testing service for Mass Spectrometry & Chromatography instruments to help you meet your regulatory and operational requirements and standards.
The philosophy behind our services is that we can support all the scientific instruments that we sell. Our technical department is trained and certified to offer a complete system service across multiple brands and models, including Mass Spectrometers (MS), Liquid Chromatographs (LC), Gas Chromatographs (GC), Autosamplers, Detectors & Peripherals
Remote support provides additional service through remote software to resolve instrument issues before a technician is dispatched. Our remote support team works with you via phone and software to remotely control your system to troubleshoot, repair or assist. This additional level of support allows for faster resolution of issues and ultimately reduces instrument downtime.
Application support is a service provided by our team that gives you a strategy and technique to quickly and confidently develop high-quality methods. You will learn a proven technique that will guide you step-by-step through the process of method development, applying principles that will make the process more efficient. Application support can take the form of a course, training, or development of an analytical method based on your real samples.
Omics technologies adopt a holistic view of the molecules that make up a cell, tissue, or organism. Target Analysis can provide unique solutions for bioinformatics services for proteomics and metabolomics workflows. Based on our experienced team members, we can readily meet the rigorous demands of various fields, such as life sciences, nutrition research, etc.
Customized training solutions from sample preparation to data analysis. Specially designed courses to meet today’s ever-increasing demands for analytical performance, productivity and ease of use!
Target Analysis was founded in 2013 by a team of experienced scientists and engineers.
Through the trust of our customers and partners, Target Analysis has managed to create a team with experienced and trained staff, which undertakes the installation of instruments, staff training, and after-sales support with spare parts, consumables, and certified reference materials. The company’s know-how is constantly expanding and is ready to take on any challenge to solve your analysis issues.
See how our customers are using Target Analysis’ products to transform their research and ultimately make discoveries that help change the way we see the future.
A workflow-based software platform, suitable for mass spectrometry experts and routine users alike
Accelerate analysis | Simplify routine workflows through automation
BioPharma Compass® 2021 is a wizard-driven, workflow-based software platform, suitable for mass spectrometry experts and routine users alike. The software enables the routine of biopharmaceutical analysis offering dedicated LC and MS workflows from automated measurements to report generation. Such workflows are increasingly important in biopharmaceutical development, e.g., to verify protein sequences and to quantify product and process-related heterogeneities such as modification profiles.
Comprehensive workflows for automated biopharmaceuticals characterization from acquisition to report generation in a single process.
Simplicity
Well documented and preinstalled workflow methods provide for a steep operator learning curve and fast return of investment. Automated result interpretation supports shortening analysis turn-around times.
Versatility
Adapts to user requirements and can be scaled from a single workstation to a client server network spanning a global biotech enterprise.
Compliance
The regulatory toolkit supports work under regulated conditions. The data mover enables data transfer to a protected server for utmost data security and access is limited through the database under audit trail.
Important Features to Consider
MAM analyses are enabled on the intact protein level as well as on the protein digest level
Automation – entire workflows can be automatically performed, from acquiring LC-MS data to generating a report it’s a single process
CFR 21 part 11 – compliance tools are on board, right after acquisition the data mover transfers data to a protected server
Multi-Attribute Methods (MAM) – allow to bring the focus of analysis where you need it. Fast and in-depth MAM assays are supported on the protein as well as the on the peptide level, respectively
QC analysis – high throughput analyses by ESI and MALDI provide synthesis quality information, e.g., for peptides or oligonucleotides, and provide QC reports automatically based on intact mass measurements
Ion mobility – using timsTOF instrument datasets, PASEF® data vastly increase the sequence coverage of biopharmaceuticals, the sensitivity in Host Cell Protein analysis (HCP) and provide CCS values as further molecular property of biomolecules
Workflow-based software solution
BioPharma Compass® 2021 is a wizard-driven, workflow-based software platform, suitable for mass spectrometry experts and routine users alike. Methods developed in a non-regulated environment can be locked down for routine biopharmaceutical analysis deployment. The customizable workspace adapts to the task at hand, including user interface, method development and data review, all from the comfort of your office PC.
The software enables the routine of biopharmaceutical analysis offering dedicated LC and MS workflows from automated measurements to report generation. Such workflows are increasingly important in biopharmaceutical development, e.g., to verify protein sequences and to quantify product and process related heterogeneities such as modification profiles. These Multi-Attribute Methods (MAM) are implemented in BPC 2021 to reduce report turnaround times and throughput using high resolution ESI-QTOF mass spectrometry.
MAM-assays can be carried out at the intact, domain (subunits) or peptide level using MS-only or MS/MS for top-down/middle-down and bottom-up analysis. Dedicated similarity scoring enables automatic result assessment and reporting with color-coded results to accelerate data review. Butterfly plots enable visual dataset comparisons.
Benefits
BioPharma Compass® provides answers for biopharma R&D and process development
BPC automates common biopharmaceutical analysis workflows from acquisition and analysis to full reports. Laboratories under 21 CFR Part 11 compliance will benefit from the regulatory options, including leading data security features.
MAM protein screening workflow for intact protein analysis: glycoform and heterogeneity quantification
The ultra-high resolution data from Bruker’s high resolution QTOFs and timsTOFs are uniquely beneficial to the identification of low level protein isoforms, ADCs or glycoforms during mAb characterization.
With Bruker’s patented SNAP II algorithm and True Isotopic Pattern (TIP™) data quality, monoisotopic masses – e.g., of mAb subunits – are automatically assigned with low-ppm accuracy. Scoring as key element of the workflows provides automated quality assessment and simplifies batch comparisons. Butterfly plots allow visual dataset comparison.
Middle-Down sequence analysis of deglycosylated Cetuximab Fd subunit fully confirms the sequence.
Top-Down Protein Sequencing: Sequence Variant Localization
Bruker’s market-leading MALDI-TOF/TOF and ESI-QTOF-ETD high resolution platforms make top-down and middle-down analysis straightforward.
Automatic sequence confirmation and sequence curation help with N/C-terminal status assessment (clipping variants), localization of sequence variants and other quality attributes.
Peptide Level Analysis for Sequence Confirmation, Attribute Identification and Multi Attribute Monitoring (MAM)
Peptide Mapping: BPC simplifies peptide mapping data handling for high quality sequence confirmation, PTM identification and targeted MAM assay design.
MAM Peptide Screening: Clear overviews and detailed EIC-based validation make multi-attribute methods simple, delivering reliable results quickly. Results can be used for comparability assessments and time course analysis to monitor critical quality attributes (CQAs) quickly.
Host Cell Protein (HCP) Analysis: Taking full advantage of the benefits of Bruker’s novel timsTOF Pro ion-mobility QTOF spectrometer, BPC further extends Bruker’s expertise in biopharmaceutical characterization to deep dive host cell proteins analysis (HCP) with PASEF® and provides high sequence coverage as well as single enzyme proteolytic digests from mAbs using sub 10-minute gradients.
Butterfly plot showing a deconvoluted spectrum from a test sample and a reference.Low ppm HCPs detected by PASEF®. Confirmed by CCS.
Applications
Suitable for a wide range of applications
Multi-Target Screening workflows for LC-ESI and LC-free MALDI-TOF workflows open a broad range of applications. Depending on application and throughput requirements, both ionization techniques can be used synergistically to provide fast and in-depth analysis reports. Reports can be exported in various formats to the file system. The analysis results are reported in a traffic light overview, covering different quality attributes to reduce operator time. Ion mobility data acquired on the timsTOF Pro allow to extend the molecular characterization by the highly accurate determination of collision cross sections (CCS).
A single method will work on 1000s of different samples, the information about them is provided as a sample table. The generic format supports very broad applications:
Oligonucleotide and peptide synthesis QC
Clone screening – e.g., sequence or glycoprofile based
Rapid drug substance ID testing in 15 min for Fill & Finish operations
