Biocompatible analytical FPLC Autosampler

analytical HPLC autosampler with biocompatible flow path

The Autosampler AS 6.1L can inject from up to 768 positions when equipped with microtiter plates (either high or low formats) or from up to 108 standard 1.5 ml sample vials. Sample carryover is significantly minimized thanks to a highly-effective interior and exterior needle wash procedure. This autosampler is also fast and flexible: one complete sample injection cycle takes less than one minute, including needle wash. Three different injection modes are supported; “full loop filling” (highest precision and reproducibility), “partial loop filling” (variable volumes, e.g. for dilution series) and “µl pickup” (loss-free injection of extremely small sample volumes), allowing the user to optimize sample usage. The headspace pressure function prevents bubbles from forming in the vial during sample uptake. Precolumn derivatization is supported.

With biocompatible sample path.

Sample Injection

Autosampler Flow PathBiocompatible
Maximum back pressure345 bar
Vial/plate dimensionswell plate dimensions according to ANSI SLAS 4-2004 (formerly ANSI/SBS 4-2004)
max. plate/vial height: 47 mm (incl. septa or capmat)
Injection volume range0.1 µl – 10 ml depending on sample loop
Sample loop100 µl
Dispenser syringe250 µl
Headspace pressurebuilt-in compressor, only for sample vials with septum
Switching time inj. valve< 100 ms
Piercing needle precision± 0.6 mm
Sample tray coolingnone
Vial detectionmissing vial/well plate detection by sensor
Needle washprogrammable: wash between injections and wash between vials
Wetted materialsTefzel® (ETFE), Glass, Teflon® (PTFE), Kel-F® (PCTFE), PEEK


Power supply95–240 V AC
Dimensions361 x 375 x 570 mm (W x H x D)
Weight32 kg
Ambient conditionstemperature range: 10–40 °C; 50–104 °F air humidity: 20 – 80%
Inputs2 programmable TTL inputs (next injection, freeze, stop)
Outputs1 programmable relay output (inject marker, auxiliary, alarm)
ControlEthernet (LAN)
InterfacesLAN, analog
Injection modesfull loop filling, partial loop filling and microliter pickup; PASA™ (pressure-assisted sample aspiration)
Injection precisionRSD (Relative Standard Deviation): full loop filling: <0.3%, partial loop fillings at injection volumes >5 µl: <0.5%, microliter pickup at injections>5 µl: <1.0%
Sample carryover< 0,01% under typical conditions using needle wash; < 0.005% under special conditions with extended needle wash
Injections per vialmax. 9 injections
Injection cycle timeminimum 7 s from the same vial, 14 s from different vials;<60 s for>100 µl sample injection in all injection modes, incl. 300 µl needle wash
Analysis timemax. 9 h, 59 min, 59 s
Biocompatible analytical FPLC Autosampler
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