Over time, instruments will wear, causing them not to run as smoothly or report results as accurately. Within this, part of the instruments can be replaced with new or refurbished spare parts, preventing downtime and keeping them working effectively.
Target Analysis’ repair services for GCs, HPLCs, mass spectrometers, and other lab instruments include warranty coverage, service agreements, and preventative maintenance. Whether you are seeking instrument repair or scheduling a service call for lab equipment repair.
Our experienced technicians will quickly restore your pump to top performance – regardless of its age. We offer comprehensive on-site support for vacuum components and systems, troubleshooting, maintenance, and repairs.
Target Analysis IQ/OQ/PQ procedures strictly follow good laboratory practices (GLP), which require that all laboratory instrumentation be inspected, cleaned, and maintained. We provide an independent and comprehensive testing service for Mass Spectrometry & Chromatography instruments to help you meet your regulatory and operational requirements and standards.
The philosophy behind our services is that we can support all the scientific instruments that we sell. Our technical department is trained and certified to offer a complete system service across multiple brands and models, including Mass Spectrometers (MS), Liquid Chromatographs (LC), Gas Chromatographs (GC), Autosamplers, Detectors & Peripherals
Remote support provides additional service through remote software to resolve instrument issues before a technician is dispatched. Our remote support team works with you via phone and software to remotely control your system to troubleshoot, repair or assist. This additional level of support allows for faster resolution of issues and ultimately reduces instrument downtime.
Application support is a service provided by our team that gives you a strategy and technique to quickly and confidently develop high-quality methods. You will learn a proven technique that will guide you step-by-step through the process of method development, applying principles that will make the process more efficient. Application support can take the form of a course, training, or development of an analytical method based on your real samples.
Omics technologies adopt a holistic view of the molecules that make up a cell, tissue, or organism. Target Analysis can provide unique solutions for bioinformatics services for proteomics and metabolomics workflows. Based on our experienced team members, we can readily meet the rigorous demands of various fields, such as life sciences, nutrition research, etc.
Customized training solutions from sample preparation to data analysis. Specially designed courses to meet today’s ever-increasing demands for analytical performance, productivity and ease of use!
Target Analysis was founded in 2013 by a team of experienced scientists and engineers.
Through the trust of our customers and partners, Target Analysis has managed to create a team with experienced and trained staff, which undertakes the installation of instruments, staff training, and after-sales support with spare parts, consumables, and certified reference materials. The company’s know-how is constantly expanding and is ready to take on any challenge to solve your analysis issues.
See how our customers are using Target Analysis’ products to transform their research and ultimately make discoveries that help change the way we see the future.
Industry-leading SPR system offering the highest performance from assay development to initial screening
High throughput Array of eight channels/three spot enables 8800 interactions in 24 hours Analytical Biosensor for the Real-Time, Label-Free
From screening and kinetics, to epitope binning and thermodynamics, Sierra SPR-24 Pro provides industry leading SPR performance and analysis throughput, across the widest range of applications.
Sierra SPR-24 Pro, features:
Highest sample throughput on the market
4400+ samples assayed per day
Integration into fully automated environment via its API
Full kinetic analysis of 2 interactions per assay cycle
Choose any combination from 1 to 8 needles for optimum performance, flexibility and range of applications.
Robust
Designed to perform all SPR applications and capable of handling crude samples such as cell lysates.
24 sensor spots
Simultaneous analysis of up to 8 samples injected over 24 sensor spots.
Productivity
The 8×3 channel/spot array allows multiple controls or targets on a single sensor chip for maximum read out per single sample injection.
Important Features to Consider
Analytical biosensor for real-time, label-free characterization of molecular interactions
Continuous Flow SPR Analysis
The SPR-24 Pro system is a continuous flow biosensor, delivering sample and reagents to the detection sensors as continuously flowing streams. When sample or reagent injection stops, a “continuous flow buffer” is passed over the sensors.
The formulation of the continuous flow buffer in SPR assays can have a significant impact on the molecular interactions being measured. In many applications, measuring target interactions in a variety of buffer environments is required.
Frame Inject
The Frame Inject feature in the Sierra SPR®-24 Pro system allows the investigation of condition dependent binding / mode of action studies. The feature requires just a fraction of each buffer condition that replaces the system buffer while usage. The pre-association, as well as the dissociation occurs under the conditions, that should be investigated. After dissociation end, frame solution buffer is replaced and system buffer is flowing through the microfluidic system again. Thus experimental time and reagent costs are kept low. The same buffer can be directed to all flow cells, or up to eight different buffers can be assayed simultaneously.
Maximising performance with individual needle control
Individual Needle Control
The individual needle control (INC) feature in the Sierra SPR®-24 Pro system allows the eight sample pickup needles to be operated independently as well as in unison. Researchers have the flexibility to choose any combination of 1 – 8 needles to design their optimal assay. Individual needle control maximizes the performance, flexibility, and scope of applications with the Sierra SPR®-24 Pro, while also saving time, materials, and resources when throughput is not the main requirement. The eight-needle probe head can simultaneously process 8 sample or reagent solutions. Using the INC feature, users can choose to use any number and/or combination of needles at any time during analysis.
Benefits
Throughput on demand
The Sierra SPR®-24 Pro delivers faster throughput across a wide range of applications, from kinetic assays with a different target on each sensor to detailed analysis employing multiple in-line controls.
The system uses Bruker’s Hydrodynamic Isolation (HI) continuous flow microfluidic technology to address samples as flowing streams onto the 24 spot SPR+ sensor array. When integrated with an optional plate handling robot, the Sierra SPR®-24 Pro instrument can assay more than 4400 samples per day, generating more than 8800 control subtracted binding responses.
Sierra SPR®-24 Pro can be easily integrated into an automated scheduling software via API.
Throughput with performance
The flexible Sierra SPR®-24 Pro system is ideal for high throughput applications. It offers 24 detection spots, which are addressed by 8 injection needles. Individual needle control (INC) gives researchers the option to choose any combination of 1 to 8 needles, to optimize the performance, flexibility and scope of applications.
The 24-sensor detection array is laid out in 8 flow cells, each containing 3 sensors. Up to 8 samples can be analyzed simultaneously, generating up to 24 binding measurements per analysis cycle. All 24 sensors can also be addressed fully independent of the others, providing maximum assay design flexibility.
The versatile system can also save time and materials in the lab, particularly if throughput is not the main requirement.
Up to eight buffers can be used simultaneously in the instrument, using the frame inject feature. The ability to evaluate different pHs, ionic strength, detergent or solvent concentration, as well as the effect of co-factors or inhibitors, in a single assay results in simpler, optimized assays that ultimately increase throughput and productivity. The four-sensor per channel design provides maximum flexibility for control analysis, while maintaining throughput for the most complex analyses.
Enhanced productivity
The design of Sierra SPR®-24 Pro maximizes control analysis flexibility, enabling high throughput for the most complex analyses. Samples can be simultaneously assayed on two controls as well as on the active sensor.
Early analysis of non-specific binding to matrix proteins such as HSA or BSA can be critical. Additional in-line control not only halves the number of assay cycles required but can also improve data quality by eliminating potential variations between multiple sample preparations.
From initial assay development to pre-defined method templates, the Sierra SPR Control Software provides the perfect solution for every use case. It combines the flexibility of the hardware with an easy-to-use drag and drop method editor. A well-defined plate and method library supports personal workflow structuring and the data view allows real-time visual monitoring of flow cells
Applications
Tackling Challenging Targets with High-Throughput Biophysical Screening at Novartis
Learn in this note how multiplexing, automation and automated data analysis with Genedata Screener take SPR to the next level in this real-life example.
How to influence ligand density using amine coupling
Finding the ideal immobilization level to obtain optimal kinetic measurements is critical. Here we examine the influencing parameters on different example targets.
Screening and characterization of small molecule binding to protein targets
Real-time, label-free (RT-LF) analysis by SPR detection is a powerful tool for the biophysical characterization of small molecule drugs and drug candidates
