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timsMRMS

An eXtreme combination for greater depth and confidence in the analysis of high complexity samples

The timsMRMS by Bruker is the next generation of Magnetic Resonance Mass Spectrometry, combining the power of MRMS with trapped ion mobility (tims) to deliver a new level of analytical performance. This advanced system provides exceptional depth, accuracy, and confidence when analyzing highly complex samples.

Many application areas remain challenging, even with advanced sample preparation and separation techniques. The timsMRMS is designed to address these challenges across fields such as MALDI tissue imaging, biofuels and petroleum research, structural isomer analysis, battery materials, and environmental monitoring of air, soil, and water, including contaminants such as PFAS.

By adding TIMS directly before MRMS detection, the system enables the separation of isomeric and isobaric compounds while also providing CCS values for more confident molecular characterization. This makes it a powerful solution for laboratories working with complex chemical mixtures that require maximum analytical detail.

The result is unmatched insight, accuracy, and confidence for demanding research and analytical applications.

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timsMRMS

Key Features

  • Dual ESI/MALDI source – Fast and effortless switching between ionization modes.
  • Smartbeam 3D laser and microGRID technology for high spatial resolution imaging.
  • Proprietary gated TIMS for accurate CCS values and detection of isomeric diversity
  • High capacity collision cell that enables continuous accumulation of selected ions (CASI) and Q-CID.
  • ParaCell with 2xR capability delivering ultra-high mass resolution and accuracy.
  • Heated cathode – accessibility to all modes of ExD fragmentation

MRMS

Next-generation MRMS, powered by trapped ion mobility and world-class MS performance

Enhanced specificity and selectivity with TIMS

TIMS supports the detection of isomeric diversity by adding accurate collision cross-section data, helping achieve greater molecular specificity — all within the same analytical workflow.

Versatility

One of the key strengths of MRMS is its versatility. The new timsMRMS combines MALDI and ESI capabilities, supporting flexible analysis across different research workflows. Structural characterization can be performed using Q-CID and/or ExD fragmentation, making it a powerful MS platform for advanced molecular research.

Unrivaled MS Performance

The timsMRMS delivers exceptional performance in mass resolving power, dynamic range, and mass measurement accuracy. These capabilities are essential for the reliable detection and confident identification of unknown compounds in highly complex mixtures.

Approachability

Equipped with the Maxwell magnet, the timsMRMS does not require liquid cryogens and can be installed in almost any MS laboratory. Its updated instrument control automation, including features such as auto shim, simplifies operation and allows researchers to focus more on the scientific question rather than the complexity of the system.

Application Areas

Environmental and Energy

Environmental and energy-related samples, such as DOM, bio-oils, crude oil, and battery materials, contain highly complex chemical mixtures that are often difficult to separate before MS analysis.
The timsMRMS addresses this analytical challenge by combining TIMS-based gas-phase fractionation with ultra-high mass resolving power and mass accuracy. This enables deeper detection of chemical diversity, including isomeric species, supported by CCS values for more confident feature annotation.

MALDI Imaging

MALDI imaging of animal or human tissue requires precise spatial mapping of complex molecular signatures. timsMRMS MALDI instruments combine Bruker’s smartbeam 3D laser, microgrid stage, and ultra-high mass resolving power to deliver high spatial resolution and deeper molecular detail at the cellular level.
This enables greater detection depth and more confident identification of molecular features, including closely related species separated by less than 10 mDa.

Environmental and Energy

timsMRMS enables the study of native-state proteins and noncovalent complexes, including their structure, stability, and unfolding pathways.
Soft TIMS separation helps preserve native protein conformations, while controlled collisional activation can induce unfolding for CIU studies. This allows researchers to separate and examine intermediate conformations with TIMS and further investigate protein structure using ExD methods.

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