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Target Analysis’ repair services for GCs, HPLCs, mass spectrometers, and other lab instruments include warranty coverage, service agreements, and preventative maintenance. Whether you are seeking instrument repair or scheduling a service call for lab equipment repair.
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Target Analysis IQ/OQ/PQ procedures strictly follow good laboratory practices (GLP), which require that all laboratory instrumentation be inspected, cleaned, and maintained. We provide an independent and comprehensive testing service for Mass Spectrometry & Chromatography instruments to help you meet your regulatory and operational requirements and standards.
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See how our customers are using Target Analysis’ products to transform their research and ultimately make discoveries that help change the way we see the future.
An eXtreme leap in deep proteoform sequencing and advanced structural elucidation
The timsOmni™ by Bruker integrates advanced trapped ion mobility spectrometry (TIMS) with the Omnitrap® platform, enabling true omnidirectional MSⁿ workflows. With ultra-fast sequencing speeds, electron-based fragmentation (ECD/EID), and collision-induced unfolding (CIU), it delivers deep insights into proteoforms, post-translational modifications, and complex biomolecules. Ideal for both top-down and bottom-up approaches, it offers unmatched structural resolution and functional proteomics capabilities. Powered by the NEOS source and OmniScape™ software, timsOmni is designed to push boundaries in biologics research, structural biology, and drug discovery.
MS n eXd for multiple stages of ion activation and dissociation:
Multi-stage trapped eXd fragmentation with charge state dependent reaction times and precise modulation of electron energy to access diverse fragmentation schemes.
Ion enrichment technology for deep sequencing and structural elucidation:
Signal amplification via ion enrichment and MSn eXd using omni-directional ion transfer for advanced ion processing workflows.
Athena Ion Processor (AIP) for broader m/z range detection:
Optimized release of ions depending on the application, addressing mass discrimination effects across a very widem/z range and boosting sensitivity.
Charge Data-Dependent Acquisition (cDDA):
On-the-fly charge state deconvolution on LC time scales for intelligent quadrupole isolation of proteoforms across a wide dynamic range.
Extended m/z range quadrupole isolation:
<4500 m/z quadrupole isolation in trans mission mode and 150 to >10,000 m/z omni-Q2 isolation in trapping mode
TIMS-MS
Elevate MS and MSn Sensitivity to New Heights
Deep Sequencing
Experience unparalleled full scan MS and MSn sensitivity by leveraging the omnidirectional, multistage MSn eXd workflow for enrichment and signal amplification, thanks to the unique Omnitrap® platform design.
Electron Control
Unlock a broad range of electron energy levels and leverage the Omnitrap® technology’s multimodal and trapped eXd capabilities to comprehensively sequence your target proteins.
Accuracy
Leverage TIMS separation for accurate CCS values to determine conformational heterogeneity and use collision induced unfolding for insights into the secondary structure of proteins.
Versatility
Built upon the tried and tested timsTOF Ultra 2 platform, gain access to all PASEF® modi for bottom-up measurements and gain the full suite of Omnitrap® workflows for top-down analysis.
Introducing the timsOmni™
Leverage advanced structural elucidation and deep proteoform sequencing with MSn eXd coupled to the power of TIMS. timsOmni™ features a unique blend of technology to deliver maximum versatility:
TIMS for accurate CCS values to determine conformational heterogeneity
Collision-induced unfolding to explore the conformational landscape of biomolecules
Precise control of electron-based fragmentation for detailed molecular profiling
Omnidirectional MSn combined with ion accumulation for unmatched sensitivity
Trapped eXd mode for optimal precursor utilization, boosting fragment ion yield
Utilization of all PASEF® modes for bottom-up proteomics and multiomics
Experience Unparalleled MS and MSn sensitivity
timsOmni™ features unparalleled full scan MS and MSn sensitivity through omnidirectional MSn and precursor enrichment for signal amplification of the lowest abundance ions.
By precise modulation of selected ion packets, any ion irrespective of its intensity, can be targeted for superior electron-based fragmentation. Made possible by the omnidirectional multi-stage MSn eXd workflow.
Precise modulation of electron energy and reaction time
Precisely tune electron energy to investigate various fragmentation regimes and adjust eXd reaction time for optimal results. With access to the entire electron fragmentation landscape, design new solutions toward deep sequencing and structural elucidation.
Trapped eXd
In trapped ion eXd mode, precursor ions are confined and rapidly fragment upon electron irradiation. Adapting the trapping time enables to boost the fragment yield and reach optimal precursor consumption (>90%). This unique capability differs from traditional passthrough electron-based fragmentation techniques.
Optimum electron energies are identified for the electron capture and ionization of ubiquitin [M+8H]8+ ions by tracing the signal of the charge-reduced [M+8H]7+● and the charge-increased [M+8H]9+● product ions as a function of electron energy.
Top-down proteomics with charge DDA
Charge DDA (cDDA) enables on-the-fly charge-state deconvolution during LC–MS analysis, allowing precise targeting of coeluting proteoforms across a wide dynamic range and eliminates redundant fragmentation of highly abundant species.
By dynamically shifting the isolation window to non-overlapping regions of the m/z spectrum, cDDA significantly reduces chimeric spectra.
Applications
Sequencing Antibody Complementarity-Determining regions
Comprehensive ion sequence ladders ideal for de novo sequencing and human plasma repertoire profiling.
Analysing and monitoring antibody levels in both healthy individuals and patients in need of treatment is critical for characterizing the progression of a disease, identifying patients with delayed symptom onset and predicting potential long-term immunity.
Comprehensive ion sequence ladders are essential to characterize the antibodies’ unique Complementarity-Determining Regions (CDRs). CDRs are the hypervariable loops within the variable domains of the light and heavy chains, primarily responsible for an antibody’s selectivity and affinity towards a specific antigen.
CDR sequencing refers to the process of identifying the exact amino acid sequences within these loops to confirm identity, assess potential mutations, or facilitate antibody
Superior eXd efficiency for CDR sequencing is enabled by:
High capacity eXd section for storing and processing >10M charges in a single scan
Bright electron source with fine energy control for fastest eXd reactions
Precise control of eXd reaction time for maximum precursor ion consumption
Enhanced signal-to-noise MS2 for maximal sequence coverage
Deep characterization of oligonucleotides in negative ion mode by MSn
DNA and RNA are essential for maintaining cellular homeostasis through their roles in protein translation pathways and gene regulation via epigenetics or interfering RNAs. They have already proven to be valuable drug modalities in several disease areas.
Characterizing endogenous RNA modifications is key to understanding biological processes. However, with a limited number of canonical nucleotides and many isobaric modifications such as methylation, precise sequencing of these molecules remains a challenging task.
Oligonucleotides are negatively charged, and their characterization requires alternative fragmentation techniques. The highly versatile eXd sourceproduces high-energy electrons to form radicals in negative mode via Electron Detachment Dissociation (EDD) and is particularly effective for intact top-down characterization of oligonucleotide therapeutics.
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