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Cannabis Purifier

Preparative HPLC system for batch purification of single cannabinoids from cannabis extracts

Preparative system with ternary gradient pump, UV-detector, injection and fractionation valve

The AZURA Cannabis Purifier is a dedicated preparative system to purify cannabinoids from cannabis extracts. The HPLC layout consists of a pump with ternary LPG valve block and a HPLC docking station equipped with a variable single wavelength UV detector an injection and a fractionation valve for 11 fractions and waste. The system is designed for method development und small volumes of sample in a flow rate range between 10 to 80 ml/min at maximum 400 bar. The system is controlled by the intuitive and touch-optimized Mobile Control, which is installed on a tablet. The software has a simple function for threshold based fractionation. Depending on the value of the detector signal the target substances/peaks are collected automatically. The purification of CBD from a cannabinoid oil is shown exemplarily.

Due to its modular design, the system can be easily up scaled to higher flow rates by simply replacing the pump head, valves, flow cell and capillaries. The basic devices do not need to be replaced. The next scale-up level allows flow rates up to 200 ml/min at 200 bar. The 1/16″ capillaries are exchanged for 1/8″ capillaries. Higher sample volumes are injected via a channel of the gradient pump. The modules of the HPLC docking station and the valves are exchanged within minutes and allow to flexibly adapt the system to changing purification tasks.

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Cannabis Purifier: Preparative HPLC system for batch purification of single cannabinoids from cannabis extracts

Key Features

  • Customized solutions
  • Certified quality management
  • Flexible and modular
  • Configure your system from injection to collection

Specifications

System type Pilot
Gradient lpg
Max. flow rate 100 ml/min
Maximum delivery pressure [MPa] 40 MPa
Maximum delivery pressure [psi] 5800 psi
Maximum delivery pressure [bar] 400 bar
Detector Variable single wavelength detection UV/VIS
Injection automatic injection
Fractionation multi-position valve
Software PurityChrom

 

Purification Flow Path

Purification of Cannabidiol (CBD) from CBD Oil

Chromatogram of Analysis

Chromatograms of analysis before (–) and after (–) purification

  • 1 Cannabigerol
  • 2 Cannabidiol
  • 3 Δ9-Tetrahydrocannabinolic acid (Δ9-THCA)

System Components

Classical Start-Up Kit for semi-prep HPLC systems with 1/16″ connections and 50 – 100 ml/min

Classical Start-Up Kit for semi-prep HPLC systems with 1/16″ connections and 50 – 100 ml/min

AZURA® start-up kit 1/16", stainless steel, semi-prep, capillary kit
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Multi-injection valve, DLC stainless steel

Multi-injection valve, DLC stainless steel

DLC stainless steel multi-injection valve for more sophisticated separation tasks. (1/16", 500 bar, 0.75 mm bore size)
Operated: electrical by VU 4.1
Port number: 8
Positions: Multiposition
Capillary connection: 1/16"
Max. pressure [bar]: 500 bar
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Dynamic mixer

Dynamic mixer

Dynamic mixing chamber (250 V), stainless steel, preparative, 1/8“, up to 250 bar, 5.9 ml mixing volume
Mixing volume: 5.9 ml
Pressure rating: max. 250 bar (25 MPa)
Recommended flow rate : < 100 ml/min
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AZURA LPG ternary module for Pump P 2.1L

AZURA LPG ternary module for Pump P 2.1L

LPG module for Pump P 2.1L ternary up to 220 ml/min (stainless steel)
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AZURA P 2.1L

AZURA P 2.1L

AZURA® Pump P 2.1L with 100 ml pump head (stainless steel)
Max. flow rate: 100 ml/min
Pump head materials: Stainless Steel
Gradient: Isocratic
Pump features: Piston seal wash, Leak management, Purge valve (manual), RFID for automatic pump head detection, Active pulsation compensation, Integrated pressure sensor
Maximum delivery pressure [MPa] : 40 MPa
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AZURA L tubing guide

AZURA L tubing guide

Sorting of 1/8" and 1/16" tubings single-sided of AZURA L devices — 2 rows with each 16 holes
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Multiposition valve, 16 Port

Multiposition valve, 16 Port

Multiposition valve, 16 Port, DLC stainless steel, POM, 1/16", 100 bar, 0.6 mm bore size
Operated: electrical by VU 4.1
Port number: 16
Positions: Multiposition
Material: Stainless Steel
Capillary connection: 1/16"
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Customizable docking station for pumps, valves and detectors – ASM 2.2L

Customizable docking station for pumps, valves and detectors – ASM 2.2L

Left module: UV detector UVD 2.1S - EDA03XA Middle module: Valve drive VU 4.1 - EWA04 Right module: Pump P 4.1S, 10 ml, stainless steel - DPG22EA
Left module: UV detector UVD 2.1S - EDA03XA
Middle module: Valve drive VU 4.1 - EWA04
Right module: Pump P 4.1S, 10 ml, stainless steel - DPG22EA
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Preparative UV Flow Cell

Preparative UV Flow Cell

0.5 mm path length, 3 µl, 1/16", 200 bar, stainless steel, classical KNAUER flow cell
Flow cell type: Preparative UV flow cell
Path length : 0.5 mm
Capillary connection : 1/16''
Max. flow rate: 250 ml/min
Flow cell volume : 3 µl
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Display software for AZURA devices with data acquisition incl. tablet

Display software for AZURA devices with data acquisition incl. tablet

Mobile Control Chrom with data acquisition, including tablet and mount
Software name: Mobile Control Chrom - display software for AZURA devices with data acquisition
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Mounting bracket AZURA L

Mounting bracket AZURA L

Mounting bracket AZURA® L for KNAUER manual injection valves
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Tool kit AZURA

Tool kit AZURA

Tool Kit AZURA® for systems with PEEK or pre-cut capillary kits
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AZURA Eluent tray E 2.1L

AZURA Eluent tray E 2.1L

AZURA® Eluent tray E 2.1L for AZURA® devices with a capacity of 6 x 1 l bottles or 4 x 2.5 l bottles or 2 x 5 l bottles, (delivery without bottles)
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