Preparative HPLC

Preparative HPLC systems.

Scalable and adaptable purification solutions.

The general objective of preparative chromatography is to isolate, purify and collect your target compounds. Preparative applications are often initially performed on an analytical level and need to be upscaled. Depending on the desired scale, the requirements for a preparative system differ in eluent supply, sample injection, column, and detection.

Customized systems to meet your chromatography scale-up and purification challenges. Benefit from our experience in preparative chromatography. AZURA® preparative LC systems are the perfect solution for frequently changing separation tasks – from milligram to kilogram scale. Design your preparative HPLC system to your needs and combine flexibility and reliability. The Preparative LC systems are tailor-made for you.

CUSTOMIZED PURIFICATION

Configure your prep HPLC system from injection to detection and choose between different materials, flow rates, valves and detectors. Due to the flexible design of our devices, you can easily change parts like pump heads or flow cells and integrate all components of the compact into the pilot-scale system. 

The AZURA® Prep LC systems can be used for special separation modes like peak recycling and stacked injections.

We Can Help you to configure your system and choose the best software for you.

PURIFICATION STRATEGY
PRIORITIZE PURITY, THROUGHPUT OR YIELD?

The dependencies between throughput, purity and yield always have to be considered in HPLC purifications. Whatever priority you decide for, with the AZURA preparative systems you can successfully adapt.

UPSACALING FROM ANALYTICAL
TO PREPARATIVE METHODS

The modular AZURA Preparative HPLC platform offers you the opportunity to build a purification system best suited to your needs.

The AZURA Pilot Prep LC is the ideal solution for your upscaling tasks. The 100 ml pump head allows you to run your system under analytical conditions before adapting your method to the preparative scale.

FLEXIBILITY AND PERFORMANCE
WITH MODULAR COMPONENTS

PEAK AND SOLVENT
RECYCLING

A separation can be much more demanding after upscaling from analytical to preparative scale. In many cases a baseline separation is not possible anymore, so time and money consuming method development or hardware adjustments are necessary. The AZURA Prep LC system is well-suited to apply the peak recycling technique to solve demanding resolution tasks. Additionally, solvent recycling can be applied to save eluent, if it can be considered clean.

Peak recycling basically elongates the separation length of the column by using the column bed multiple times. Most preparative chromatography users are familiar with the term but do not necessarily know in which cases this special solution is beneficial. The technology allows the eluted substances to be led back to the column after these have passed through it. Thereby, critical peak pairs that run together can be separated further with each cycle. The only requirement for peak recycling is an isocratic separation method, one additional valve, and a T-fitting.

Do you need more details or a quote?

We Can Help

Please send us your request.
We are happy to answer your questions about our products and services.

+30 2310 580765

sales@targetanalysis.gr

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