HPLC system for automated LC column testing

Automated testing of up to 8 columns

The basic system configuration consists of an isocratic pump, an autosampler, a column selection assistant and a variable single wavelength UV detector as well as the customizable chromatography software including the column test option.

Quality control of analytical and preparative HPLC columns as well as FPLC columns is a crucial step for column manufacturers or facilities which strongly rely on liquid chromatography like contract laboratories. Inspecting one column after another is work-intensive and time-consuming and therefore target for automation. Once started, the automated column testing requires no further support. For overnight measurements, results are available the next morning. Alternatively, column tests can be performed continuously. Columns that have already been examined can be removed during the test process and exchanged for new, untested columns.

After the quality test, a test certificate displaying the column and method specifications, the chromatogram and the result table is generated for each column. The design and content of the column test report can be customized. An easily editable parameter list manages the specifications and test methods of several thousand columns, so that the right method for a column test can easily be chosen via the column specification. An intelligent search allows a quick selection of the desired column in the software. For a fast and intuitive operation, the column test option features an own user interface. The number of clicks to setup the test sequence has been reduced to a minimum.

The hardware as well as the software is flexible allowing different system layouts. Depending on the column specifications, a high pressure, a biocompatible or a high flow rate system variant are available. Even the number of columns to be tested can be adapted depending on the size of the columns. The default system processes up to 8 columns. For smaller columns a system layout for 16 columns is feasible. 

The LC Column Test System assures the quality of HPLC/FPLC columns at a minimum time and effort and is recommended for users that test LC columns regularly. Therefore, it is tailor-made for LC column manufacturers and any lab working with high-throughput column testing.

HPLC system for automated LC column testing

Specifications

Application area HPLC
Pump system Isocratic
Gradient None
Injection Autosampler
Detector Variable multiwavelength detection UV/VIS
Software Mobile Control
Pressure 862 bar
Column thermostat No

 

System Components

Compact Single Wavelength UV-Detector for Liquid Chromatography and Process Technology

Compact Single Wavelength UV-Detector for Liquid Chromatography and Process Technology

AZURA® Detector UVD 2.1S with deuterium lamp without flow cell, incl. test cell
Detector type: Variable single wavelength UV detector
Detection channels: 1
Wavelength range: 190 - 500 nm
Linearity : > 2.0 AU at 274 nm (ASTM E1657-98)
11.6″ Tablet without Mobile Control Software

11.6″ Tablet without Mobile Control Software

for Mobile Control (Chrom)
Column holder for ASM 2.2L

Column holder for ASM 2.2L

Column holder for slots without an plug-in module
Customizable docking station for pumps, valves and detectors – ASM 2.2L

Customizable docking station for pumps, valves and detectors – ASM 2.2L

Left module: UV detector UVD 2.1S - EDA03XA Middle module: Valve drive VU 4.1 - EWA04 Right module: Pump P 4.1S, 10 ml, stainless steel - DPG22EA
Left module: UV detector UVD 2.1S - EDA03XA
Middle module: Valve drive VU 4.1 - EWA04
Right module: Pump P 4.1S, 10 ml, stainless steel - DPG22EA
Preparative UV Flow Cell

Preparative UV Flow Cell

0.5 mm path length, 3 µl, 1/16", 200 bar, stainless steel, classical KNAUER flow cell
Flow cell type: Preparative UV flow cell
Path length : 0.5 mm
Capillary connection : 1/16''
Max. flow rate: 250 ml/min
Flow cell volume : 3 µl
Cost-effective, isocratic HPLC pump

Cost-effective, isocratic HPLC pump

AZURA® Pump P 6.1L isocratic, without degasser, with 10 ml pump head (stainless steel)
Max. flow rate: 10 ml/min
Pump head materials: Stainless Steel
Gradient: Isocratic
Pump features: Active pulsation compensation, RFID for automatic pump head detection, Integrated pressure sensor, Purge valve (manual), Leak management, Piston seal wash
Maximum delivery pressure [MPa] : 86 MPa
Tool kit AZURA

Tool kit AZURA

Tool Kit AZURA® for systems with PEEK or pre-cut capillary kits
Start-Up Kit with flexible, precut capillaries for analytical HPLC and UHPLC systems with 1/16″ connections

Start-Up Kit with flexible, precut capillaries for analytical HPLC and UHPLC systems with 1/16″ connections

Set of precut capillaries 0.18 mm ID, fittings, connectors and adapters, yellow
WiFi router, 8x GBit RJ-45 ports, for connection of AZURA devices with a PC

WiFi router, 8x GBit RJ-45 ports, for connection of AZURA devices with a PC

WiFi router, 8x LAN GBit RJ-45 ports, 1x WAN GBit RJ-45 port
Autosampler AS 6.1L

Autosampler AS 6.1L

AZURA® Autosampler AS 6.1L analytical HPLC autosampler, 862 bar
Maximum back pressure: 862 bar
Sample loop: 100 µl
Sample tray cooling: None
Autosampler Flow Path: Analytical
Black GL45 Safety Cap with air valve and fittings

Black GL45 Safety Cap with air valve and fittings

PTFE membrane keeps dust and other contaminants from the air
AZURA Eluent tray E 2.1L

AZURA Eluent tray E 2.1L

AZURA® Eluent tray E 2.1L for AZURA® devices with a capacity of 6 x 1 l bottles or 4 x 2.5 l bottles or 2 x 5 l bottles, (delivery without bottles)

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