SMB – biocompatible system for continuous chromatography in lab scale

System solution for SMB

The AZURA Lab SMB System is optimized for the multicolumn separation of binary mixtures of small or biomolecules in gram-scale. The SMB System A29100 is the standard configuration of our AZURA Lab SMB. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assitants ASM 2.2L. The high pressure range and the biocompatibility as well as the flexibility of the multiposition valves make this system the perfect solution for SMB chromatography.

SMB – Biocompatible – for continuous chromatography in lab scale

Specifications

Recommended flow rate 2-30 ml/min
Column dimensions up to 30 mm ID
Column configuration 2:2:2:2, 1:1:1:1, 1:3:3:1
Operating modes SMB
Supported software packages PurityChrom® MCC
Wetted materials PAEK

How AZURA® SMB works

System configuration

  • The standard AZURA® SMB systems consists of four pumps and seven multi-position valves. The devices are arranged as follows:
  • Three pumps (Extract, Raffinate, Eluent) are placed inside the SMB cycle.
  • The feed pump is placed outside the SMB cycle.
  • Four valves are placed at the pump outlets.
  • Three valves are placed at the pump inlets. The feed pump inlet is not connected to a multiposition valve.

Due to this configuration the SMB system can be used very flexible for many different separation modes. Additionally to the process stability AZURA® SMB systems are outperforming every other SMB system on the market regarding material and configuration flexibility as well as the usable pressure range.

System Components

PFA tubing, chemically resistant, translucent

PFA tubing, chemically resistant, translucent

PFA tubing, 1/4'' OD, 4 mm ID, translucent, max. pressure 15.4 bar, variable length
Software to control your Simulated Moving Bed Chromatography System

Software to control your Simulated Moving Bed Chromatography System

Easy to use, user-friendly, 21 CFR part 11 compliant
Software name: PurityChrom® MCC
Upgrade-Kit Flowmeter for AZURA Pilot SMB (Set)

Upgrade-Kit Flowmeter for AZURA Pilot SMB (Set)

CORI-Flow M14, monitor your process, maximum security
Table AZURA SMB Pilot

Table AZURA SMB Pilot

On Wheels - The Azura SMB Pilot System
AZURA P 2.1L

AZURA P 2.1L

AZURA® Pump P 2.1L with 500 ml pump head (stainless steel)
Max. flow rate: 500 ml/min
Pump head materials: Stainless Steel
Gradient: Isocratic
Pump features: Piston seal wash, Leak management, Purge valve (manual), RFID for automatic pump head detection, Active pulsation compensation, Integrated pressure sensor
Maximum delivery pressure [MPa]: 10 MPa
8-port GBit switch for connection of AZURA devices with a PC

8-port GBit switch for connection of AZURA devices with a PC

8-port LAN GBit switch NetGear GS108GE, 8x RJ-45, GBit, Auto MDI-X, power plug UK, US or AUS
AZURA P 2.1L

AZURA P 2.1L

AZURA® Pump P 2.1L with 100 ml pump head (stainless steel)
Max. flow rate: 100 ml/min
Pump head materials: Stainless Steel
Gradient: Isocratic
Pump features: Piston seal wash, Leak management, Purge valve (manual), RFID for automatic pump head detection, Active pulsation compensation, Integrated pressure sensor
Maximum delivery pressure [MPa] : 40 MPa
Manual injection valve, 6 Port

Manual injection valve, 6 Port

Manual injection valve, 6 Port, DLC stainless steel, POM, 1/16", 100 bar, 0.75 mm bore size
Operated: manual
Port number: 6
Positions: 2
Material: Stainless Steel
Capillary connection: 1/16"
Chromatography Workstation for PurityChrom® and ClarityChrom®, PC with 24″ monitor

Chromatography Workstation for PurityChrom® and ClarityChrom®, PC with 24″ monitor

Desktop PC (SFF) for PurityChrom® and ClarityChrom® with 24" monitor, English edition Windows 10 Prof. 64-bit English, Intel® Core™ i5, 8 GB RAM, 256 GB SSD, two network cards

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